Karyopharm Therapeutics Inc. financials
Source: EDGAR filings · Built 2026-06-02T03:24:33Z
Custom taxonomy namespace:
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Key metrics by reporting period
Up to six most-recent periods side-by-side. Rows are the curated key lines — revenue, margins, cash, debt, equity, cash-flow totals, plus the derived and valuation metrics we compute on top. For every tag a filer reported in one period, use the single-filing drilldown below.
Derived Metrics
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Free Cash Flow | -75.37M | -127.63M | -92.72M | -149.67M | -107.33M | -160.38M |
| EBITDA | -90.41M | -119.10M | -129.01M | -141.58M | -97.48M | -170.88M |
| Working Capital | 11.09M | 64.20M | 164.44M | 284.25M | 201.89M | 216.33M |
| Net Debt | -53.83M | -55.33M | 124.78M | 43.89M | -9.88M | 45.21M |
| Operating Margin | -62.10% | -82.24% | -88.71% | -90.53% | -46.84% | -159.00% |
| Net Margin | -134.21% | -52.62% | -97.99% | -105.23% | -59.14% | -181.59% |
| Return on Equity (ROE) | 66.92% | 41.08% | 105.06% | 992.38% | 155.75% | -388.31% |
| Return on Assets (ROA) | -180.82% | -46.48% | -59.52% | -46.15% | -40.64% | -62.70% |
| Current Ratio | 1.12× | 1.70× | 3.37× | 5.31× | 3.74× | 4.59× |
| Debt-to-Equity | -0.02× | -0.04× | -1.30× | -10.75× | -2.27× | 2.59× |
| Effective Tax Rate | -0.02% | -0.07% | -0.23% | -0.22% | -0.22% | -0.16% |
| Cash Conversion Ratio | 0.38× | 1.67× | 0.65× | 0.90× | 0.86× | 0.82× |
| Accruals Ratio | -1.11× | 0.31× | -0.21× | -0.04× | -0.06× | -0.12× |
| SBC % of Revenue | 9.62% | 12.69% | 14.87% | 22.54% | 14.19% | 22.58% |
| CapEx Coverage | — | -897.79× | — | -1267.41× | -505.26× | -1105.06× |
| Free Cash Flow Per Share | $-6.89 | $-15.10 | $-12.17 | $-1.83 | $-1.43 | $-2.23 |
Valuation Metrics
Income Statement
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Revenue from Contract with Customer, Excluding Assessed Tax | 146.07M | 145.24M | 146.03M | 157.07M | 209.82M | 108.08M |
| Research and Development Expense | 125.62M | 143.23M | 138.75M | 148.66M | 160.84M | 150.81M |
| Selling, General and Administrative Expense | 105.21M | 115.44M | 131.88M | 145.40M | 143.85M | 126.42M |
| Operating Expenses | 236.77M | 264.68M | 275.57M | 299.28M | 308.09M | 279.94M |
| Operating Income (Loss) | -90.71M | -119.44M | -129.54M | -142.20M | -98.27M | -171.85M |
| Income Tax Expense (Benefit) | 43.00K | 57.00K | 323.00K | 369.00K | 268.00K | 309.00K |
| Net Income (Loss) Attributable to Parent | -196.04M | -76.42M | -143.10M | -165.29M | -124.09M | -196.27M |
| Earnings Per Share, Basic | $-17.93 | $-9.41 | $-18.79 | $-2.02 | $-1.65 | $-2.72 |
| Weighted Average Number of Shares Outstanding, Basic | 10.94M | 8.13M | 7.62M | 81.87M | 75.22M | 72.04M |
| Earnings Per Share, Diluted | $-17.93 | $-14.00 | $-18.79 | $-2.02 | $-1.65 | $-2.72 |
| Weighted Average Number of Shares Outstanding, Diluted | 10.94M | 8.46M | 7.62M | 81.87M | 75.22M | 72.04M |
Balance Sheet
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Cash and Cash Equivalents, at Carrying Value | 60.54M | 62.48M | 52.23M | 135.19M | 190.46M | 85.92M |
| Assets, Current | 103.15M | 156.46M | 233.92M | 350.16M | 275.61M | 276.53M |
| Assets | 108.42M | 164.42M | 240.44M | 358.17M | 305.31M | 313.05M |
| Long-term Debt | — | — | — | — | 169.29M | — |
| Liabilities, Current | 92.06M | 92.26M | 69.48M | 65.91M | 73.72M | 60.20M |
| Liabilities | 401.34M | 350.44M | 376.64M | 374.83M | 384.98M | 262.50M |
| Stockholders' Equity Attributable to Parent | -292.93M | -186.02M | -136.21M | -16.66M | -79.67M | 50.55M |
| Common Stock, Shares, Outstanding | 18.31M | 8.41M | 114.92M | 113.21M | 75.75M | 73.92M |
Cash Flow Statement
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Net Cash Provided by (Used in) Operating Activities | -75.37M | -127.49M | -92.72M | -149.55M | -107.12M | -160.23M |
| Payments to Acquire Property, Plant, and Equipment | 0 | 142.00K | 0 | 118.00K | 212.00K | 145.00K |
| Net Cash Provided by (Used in) Investing Activities | 43.38M | 95.47M | 7.94M | -104.26M | 141.84M | -53.69M |
| Net Cash Provided by (Used in) Financing Activities | 30.05M | 41.65M | 1.12M | 193.74M | 73.65M | 172.08M |
Derived Metrics
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Free Cash Flow | — | -11.83M | -63.54M | -57.68M | -38.98M | -25.76M |
| EBITDA | -26.75M | -17.82M | — | — | -33.18M | -31.20M |
| Working Capital | 9.03M | 11.09M | 2.59M | -1.35M | 29.87M | 64.20M |
| Net Debt | -84.36M | -53.83M | -30.74M | -31.09M | -31.37M | -55.33M |
| Operating Margin | -76.31% | -52.36% | -34.56% | -64.30% | -110.80% | -102.42% |
| Net Margin | -63.86% | -299.89% | -75.21% | -98.22% | -78.17% | -100.78% |
| Return on Equity (ROE) | 8.43% | 34.89% | 12.30% | 15.59% | 11.40% | 16.55% |
| Return on Assets (ROA) | -17.04% | -94.26% | -34.42% | -35.52% | -18.37% | -18.72% |
| Current Ratio | 1.08× | 1.12× | 1.03× | 0.99× | 1.33× | 1.70× |
| Debt-to-Equity | -0.02× | -0.02× | -0.03× | -0.03× | -0.04× | -0.04× |
| Effective Tax Rate | -0.00% | 0.07% | -0.10% | -0.11% | -0.15% | 0.35% |
| Cash Conversion Ratio | 1.01× | 0.12× | 1.92× | 1.55× | 1.66× | 0.84× |
| Accruals Ratio | 0.00× | -0.83× | 0.32× | 0.19× | 0.12× | -0.03× |
| SBC % of Revenue | 8.58% | 11.45% | 23.04% | 19.36% | 11.86% | 12.65% |
| CapEx Coverage | — | — | — | — | — | 486.98× |
| Free Cash Flow Per Share | — | $-1.08 | $-7.33 | $-6.69 | $-4.60 | $-3.05 |
Valuation Metrics
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| P/S | 0.83× | 0.92× | 0.40× | 0.27× | 0.23× | 0.04× |
Income Statement
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Revenue from Contract with Customer, Excluding Assessed Tax | 35.07M | 34.08M | 44.04M | 37.93M | 30.02M | 30.54M |
| Research and Development Expense | 33.80M | 27.67M | 30.54M | 32.79M | 34.62M | 33.30M |
| Selling, General and Administrative Expense | 26.68M | 22.77M | 26.61M | 28.48M | 27.35M | 27.19M |
| Operating Expenses | 61.83M | 51.92M | 59.26M | 62.32M | 63.27M | 61.82M |
| Operating Income (Loss) | -26.76M | -17.84M | -15.22M | -24.39M | -33.26M | -31.28M |
| Income Tax Expense (Benefit) | 1.00K | -67.00K | 34.00K | 40.00K | 36.00K | -109.00K |
| Net Income (Loss) Attributable to Parent | -22.39M | -102.20M | -33.13M | -37.25M | -23.46M | -30.78M |
| Earnings Per Share, Basic | $-1.02 | $-7.00 | $-3.82 | $-4.32 | $-2.77 | $-3.73 |
| Weighted Average Number of Shares Outstanding, Basic | 22.01M | 10.94M | 8.67M | 8.62M | 8.47M | 8.13M |
| Earnings Per Share, Diluted | $-1.24 | $-7.00 | $-3.82 | $-4.32 | $-2.77 | $-3.60 |
| Weighted Average Number of Shares Outstanding, Diluted | 24.71M | 10.94M | 8.67M | 8.62M | 8.47M | 8.46M |
Balance Sheet
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Cash and Cash Equivalents, at Carrying Value | 90.85M | 60.54M | 37.67M | 38.73M | 38.78M | 62.48M |
| Assets, Current | 126.33M | 103.15M | 89.75M | 97.87M | 120.24M | 156.46M |
| Assets | 131.42M | 108.42M | 96.23M | 104.88M | 127.71M | 164.42M |
| Liabilities, Current | 117.30M | 92.06M | 87.16M | 99.22M | 90.37M | 92.26M |
| Liabilities | 397.06M | 401.34M | 365.49M | 343.81M | 333.60M | 350.44M |
| Stockholders' Equity Attributable to Parent | -265.65M | -292.93M | -269.26M | -238.93M | -205.88M | -186.02M |
| Common Stock, Shares, Outstanding | 22.54M | 18.31M | 8.70M | 8.65M | 8.57M | 8.41M |
Cash Flow Statement
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Net Cash Provided by (Used in) Operating Activities | -22.73M | -11.83M | -63.54M | -57.68M | -38.98M | -25.81M |
| Payments to Acquire Property, Plant, and Equipment | — | 0 | 0 | 0 | 0 | -53.00K |
| Net Cash Provided by (Used in) Investing Activities | 3.20M | 5.00M | 38.38M | 33.57M | 15.29M | 14.80M |
| Net Cash Provided by (Used in) Financing Activities | 49.80M | 29.69M | 356.00K | 356.00K | 0 | 680.00K |
Raw XBRL tagging for a single filing
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Methodology
All facts on this page come straight from SEC EDGAR XBRL
company-facts filings (KPTI CIK 0001503802),
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