PROTAGONIST THERAPEUTICS, INC. financials
Source: EDGAR filings · Built 2026-06-02T03:53:20Z
Key metrics by reporting period
Up to six most-recent periods side-by-side. Rows are the curated key lines — revenue, margins, cash, debt, equity, cash-flow totals, plus the derived and valuation metrics we compute on top. For every tag a filer reported in one period, use the single-filing drilldown below.
Derived Metrics
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Free Cash Flow | 56.08M | 182.80M | -70.84M | -108.93M | -108.97M | -72.95M |
| EBITDA | -156.85M | 253.67M | -92.67M | -130.34M | -125.03M | -63.57M |
| Working Capital | 532.13M | 544.24M | 334.30M | 211.90M | 296.72M | 275.37M |
| Net Debt | -118.07M | -86.38M | -185.59M | -122.09M | -117.81M | -111.40M |
| Operating Margin | -343.63% | 58.20% | -156.09% | -494.24% | -460.01% | -225.36% |
| Net Margin | -282.83% | 63.34% | -131.59% | -479.26% | -458.94% | -231.07% |
| Return on Equity (ROE) | -21.17% | 40.75% | -23.45% | -59.09% | -41.85% | -23.66% |
| Return on Assets (ROA) | -19.48% | 36.95% | -22.06% | -51.38% | -36.11% | -20.39% |
| Current Ratio | 12.71× | 12.48× | 16.71× | 7.80× | 7.74× | 7.84× |
| Debt-to-Equity | 0.02× | 0.02× | 0.00× | 0.02× | 0.02× | 0.02× |
| Effective Tax Rate | -0.65% | 1.51% | 0.00% | 0.00% | 0.00% | -2.01% |
| Cash Conversion Ratio | -0.44× | 0.67× | 0.89× | 0.85× | 0.86× | 1.10× |
| Accruals Ratio | -0.28× | 0.12× | -0.02× | -0.08× | -0.05× | 0.02× |
| SBC % of Revenue | 99.91% | 8.64% | 48.82% | 91.05% | 59.93% | 27.59% |
| CapEx Coverage | 36.27× | 135.91× | -115.33× | -136.02× | -97.97× | -153.89× |
| Free Cash Flow Per Share | $0.88 | $2.81 | $-1.25 | $-2.22 | $-2.35 | $-2.12 |
Valuation Metrics
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| P/E Trailing (Diluted) | — | 9.13× | — | — | — | — |
| P/FCF | 99.00× | 13.74× | — | — | — | — |
| FCF Yield | 1.01% | 7.28% | — | — | — | — |
| EV / EBITDA | — | 8.95× | — | — | — | — |
| P/S | 118.78× | 5.42× | 22.05× | 20.25× | 59.80× | 30.81× |
| P/B | 8.89× | 3.49× | 3.93× | 2.50× | 5.45× | 3.15× |
Income Statement
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Research and Development Expense | 159.29M | 138.13M | 120.16M | 126.22M | 126.01M | 74.51M |
| Operating Expenses | 204.14M | 181.59M | 153.65M | 157.95M | 153.20M | 93.14M |
| Operating Income (Loss) | -158.13M | 252.84M | -93.65M | -131.37M | -125.84M | -64.52M |
| Income Tax Expense (Benefit) | 838.00K | 4.22M | 0 | 0 | 0 | 1.30M |
| Net Income (Loss) Attributable to Parent | -130.15M | 275.19M | -78.95M | -127.39M | -125.55M | -66.15M |
| Earnings Per Share, Basic | $-2.05 | $4.47 | $-1.39 | $-2.60 | $-2.71 | $-1.92 |
| Weighted Average Number of Shares Outstanding, Basic | 63.57M | 61.57M | 56.76M | 49.04M | 46.32M | 34.40M |
| Earnings Per Share, Diluted | $-2.05 | $4.23 | $-1.39 | $-2.60 | $-2.71 | $-1.92 |
| Weighted Average Number of Shares Outstanding, Diluted | 63.57M | 65.08M | 56.76M | 49.04M | 46.32M | 34.40M |
Balance Sheet
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Cash and Cash Equivalents, at Carrying Value | 128.39M | 97.25M | 186.73M | 125.74M | 123.67M | 117.36M |
| Assets, Current | 577.57M | 591.64M | 355.58M | 243.08M | 340.74M | 315.61M |
| Assets | 668.19M | 744.73M | 357.95M | 247.93M | 347.69M | 324.47M |
| Liabilities, Current | 45.44M | 47.40M | 21.27M | 31.18M | 44.02M | 40.24M |
| Liabilities | 53.48M | 69.43M | 21.27M | 32.32M | 47.67M | 44.86M |
| Stockholders' Equity Attributable to Parent | 614.71M | 675.29M | 336.68M | 215.61M | 300.02M | 279.61M |
| Common Stock, Shares, Outstanding | 62.58M | 61.04M | 57.71M | 49.34M | 47.84M | 43.75M |
Cash Flow Statement
| Concept | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 |
|---|---|---|---|---|---|---|
| Net Cash Provided by (Used in) Operating Activities | 57.67M | 184.15M | -70.24M | -108.14M | -107.86M | -72.48M |
| Payments to Acquire Property, Plant, and Equipment | 1.59M | 1.35M | 609.00K | 795.00K | 1.10M | 471.00K |
| Net Cash Provided by (Used in) Investing Activities | -49.33M | -299.48M | -39.26M | 91.47M | -15.86M | -90.97M |
| Net Cash Provided by (Used in) Financing Activities | 22.86M | 25.85M | 170.48M | 18.84M | 129.92M | 247.63M |
Derived Metrics
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Free Cash Flow | -49.16M | -37.12M | 93.20M | 95.22M | 124.82M | -29.49M |
| EBITDA | -3.24M | -49.98M | — | — | -19.07M | 126.90M |
| Working Capital | 578.91M | 532.13M | 541.48M | 567.02M | 570.75M | 544.24M |
| Net Debt | -183.94M | -118.07M | -102.96M | -157.26M | -128.29M | -86.38M |
| Operating Margin | -6.47% | -677.09% | -985.17% | -758.04% | -68.18% | 74.30% |
| Net Margin | 6.71% | -596.80% | -834.87% | -626.96% | -41.15% | 77.17% |
| Return on Equity (ROE) | 0.58% | -7.22% | -6.09% | -5.21% | -1.69% | 19.50% |
| Return on Assets (ROA) | 0.54% | -6.64% | -5.61% | -4.84% | -1.57% | 17.68% |
| Current Ratio | 17.76× | 12.71× | 13.05× | 16.97× | 17.26× | 12.48× |
| Debt-to-Equity | 0.01× | 0.02× | 0.02× | 0.02× | 0.02× | 0.02× |
| Effective Tax Rate | -65.85% | -1.52% | 0.00% | -0.50% | 0.00% | 1.49% |
| Cash Conversion Ratio | -12.94× | 0.83× | -2.41× | -2.78× | -10.76× | -0.22× |
| Accruals Ratio | 0.08× | -0.01× | -0.19× | -0.18× | -0.18× | 0.22× |
| SBC % of Revenue | 25.76% | 143.89% | 748.58% | 445.62% | 48.73% | 5.33% |
| CapEx Coverage | -227.64× | -256.77× | 65.45× | 71.12× | 230.02× | -94.12× |
| Free Cash Flow Per Share | $-0.70 | $-0.58 | $1.46 | $1.50 | $1.98 | $-0.45 |
Valuation Metrics
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| P/E Trailing (Diluted) | — | — | 102.20× | 75.71× | 62.00× | 9.13× |
| P/S | 91.40× | 118.78× | 19.83× | 16.41× | 14.41× | 5.42× |
| P/B | 10.33× | 8.89× | 6.43× | 5.14× | 4.35× | 3.49× |
Income Statement
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Research and Development Expense | 46.74M | 46.36M | 40.00M | 37.04M | 35.89M | 34.90M |
| Operating Expenses | 60.02M | 57.79M | 51.13M | 47.59M | 47.63M | 43.86M |
| Operating Income (Loss) | -3.65M | -50.35M | -46.42M | -42.04M | -19.31M | 126.78M |
| Income Tax Expense (Benefit) | -1.50M | 666.00K | 0 | 172.00K | 0 | 1.99M |
| Net Income (Loss) Attributable to Parent | 3.78M | -44.38M | -39.34M | -34.77M | -11.65M | 131.67M |
| Earnings Per Share, Basic | $0.06 | $-0.70 | $-0.62 | $-0.55 | $-0.19 | $2.13 |
| Weighted Average Number of Shares Outstanding, Basic | 65.09M | 63.57M | 63.77M | 63.51M | 62.96M | 61.57M |
| Earnings Per Share, Diluted | $0.05 | $-0.70 | $-0.62 | $-0.55 | $-0.19 | $2.01 |
| Weighted Average Number of Shares Outstanding, Diluted | 70.49M | 63.57M | 63.77M | 63.51M | 62.96M | 65.08M |
Balance Sheet
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Cash and Cash Equivalents, at Carrying Value | 193.71M | 128.39M | 113.71M | 168.54M | 139.65M | 97.25M |
| Assets, Current | 613.46M | 577.57M | 586.42M | 602.53M | 605.86M | 591.64M |
| Assets | 697.46M | 668.19M | 701.69M | 718.01M | 742.13M | 744.73M |
| Liabilities, Current | 34.55M | 45.44M | 44.94M | 35.51M | 35.11M | 47.40M |
| Liabilities | 41.99M | 53.48M | 56.25M | 49.99M | 53.08M | 69.43M |
| Stockholders' Equity Attributable to Parent | 655.47M | 614.71M | 645.44M | 668.02M | 689.05M | 675.29M |
| Common Stock, Shares, Outstanding | 64.23M | 62.58M | 62.45M | 62.11M | 61.93M | 61.04M |
Cash Flow Statement
| Concept | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 |
|---|---|---|---|---|---|---|
| Net Cash Provided by (Used in) Operating Activities | -48.94M | -36.98M | 94.65M | 96.58M | 125.36M | -29.18M |
| Payments to Acquire Property, Plant, and Equipment | 215.00K | 144.00K | 1.45M | 1.36M | 545.00K | 310.00K |
| Net Cash Provided by (Used in) Investing Activities | 90.89M | 48.81M | -98.15M | -39.59M | -94.40M | -8.72M |
| Net Cash Provided by (Used in) Financing Activities | 23.37M | 2.84M | 20.03M | 14.37M | 11.44M | 4.03M |
Raw XBRL tagging for a single filing
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Methodology
All facts on this page come straight from SEC EDGAR XBRL
company-facts filings (PTGX CIK 0001377121),
grouped by financial statement using FASB's base
us-gaap presentation taxonomy. Filers may re-parent
concepts onto different statements in their own extension
taxonomy, so a handful of rows can show up under a different
statement than on the actual 10-K / 10-Q; custom concepts and
any we couldn't map fall into Other. Hover a
cell to see the fully-qualified concept name and the filer's
description.
For the full methodology — statement grouping, the Other bucket, derived metrics, and fact tooltips — see the methodology reference for the statement grouping, the "Other" bucket, derived metrics, and fact tooltips.