Ionis Pharmaceuticals, Inc. (IONS) Stock Total Returns

Growth of $10,000 chart

2021-06-03 to 2026-06-03
to
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Investment Performance

Final Value
$21,262
Total Return
112.62%
CAGR
16.29%
Dividends
$0.00
Yield on Cost
0.00%

Rolling Returns

1-Month (21 Trading Days)
Average+1.76%
Median+0.80%
Best+56.71%
Worst-22.39%
% of Windows Positive53.5%
1-Year (252 Trading Days)
Average+25.03%
Median+12.89%
Best+194.67%
Worst-40.98%
% of Windows Positive63.8%
3-Year (756 Trading Days)
Average+39.29%
Median+20.81%
Best+124.22%
Worst-34.42%
% of Windows Positive83.6%

Risk Metrics

Maximum Drawdown -52.36%
Average Drawdown -16.52%
Drawdown Duration 410 Trading Days
Sortino Ratio 0.88
Calmar Ratio 0.31
CVaR (5%) -5.44%

Yearly Returns

Year Percentage Abs. Return Dividends Taxes Trans. Costs
2026 partial -6.69% (-15.14% ann.) $668.69 $0.00 $0.00 $0.00
2025 +126.29% +$12628.72 $0.00 $0.00 $0.00
2024 -30.90% $3089.54 $0.00 $0.00 $0.00
2023 +33.94% +$3394.23 $0.00 $0.00 $0.00
2022 +24.12% +$2412.09 $0.00 $0.00 $0.00
2021 -46.18% $4617.97 $0.00 $0.00 $0.00
2020 -6.41% $640.62 $0.00 $0.00 $0.00
2019 +11.75% +$1174.62 $0.00 $0.00 $0.00
2018 +7.48% +$747.51 $0.00 $0.00 $0.00
2017 +5.16% +$516.41 $0.00 $0.00 $0.00
2016 -22.77% $2276.76 $0.00 $0.00 $0.00
2015 +0.31% +$30.77 $0.00 $0.00 $0.00
2014 +54.97% +$5496.99 $0.00 $0.00 $0.00
2013 +281.61% +$28160.92 $0.00 $0.00 $0.00
2012 +44.80% +$4479.89 $0.00 $0.00 $0.00
2011 -28.75% $2875.49 $0.00 $0.00 $0.00
2010 -8.91% $891.09 $0.00 $0.00 $0.00
2009 -21.65% $2165.02 $0.00 $0.00 $0.00
2008 -9.97% $996.83 $0.00 $0.00 $0.00
2007 +41.64% +$4163.67 $0.00 $0.00 $0.00
2006 +112.21% +$11221.37 $0.00 $0.00 $0.00
2005 -11.19% $1118.64 $0.00 $0.00 $0.00
2004 -9.23% $923.08 $0.00 $0.00 $0.00
2003 -1.37% $136.57 $0.00 $0.00 $0.00
2002 -70.30% $7030.19 $0.00 $0.00 $0.00
2001 +108.85% +$10884.71 $0.00 $0.00 $0.00
2000 +70.00% +$7000.00 $0.00 $0.00 $0.00
1999 -51.69% $5169.08 $0.00 $0.00 $0.00
1998 +5.08% +$507.61 $0.00 $0.00 $0.00
1997 -31.60% $3159.72 $0.00 $0.00 $0.00
1996 +37.14% +$3714.29 $0.00 $0.00 $0.00
1995 +228.13% +$22812.50 $0.00 $0.00 $0.00
1994 -40.74% $4074.07 $0.00 $0.00 $0.00
1993 -30.77% $3076.92 $0.00 $0.00 $0.00
1992 -29.09% $2909.09 $0.00 $0.00 $0.00
1991 partial +37.50% (+66.55% ann.) +$3750.00 $0.00 $0.00 $0.00

Market Regimes

about
Regime Period Percentage Annual Abs. Return Dividends Taxes Trans. Costs
Dot-com bubble / TMT mania August 9, 1995 – March 10, 2000 +71.43% +12.47% +$7142.86 $0.00 $0.00 $0.00
Dot-com bust / post-bubble disinflation scare March 13, 2000 – October 9, 2002 -62.50% -31.69% $6249.86 $0.00 $0.00 $0.00
China-WTO / housing-credit / commodity boom October 10, 2002 – October 9, 2007 +92.15% +13.96% +$9214.54 $0.00 $0.00 $0.00
GFC / deleveraging / dollar shortage October 10, 2007 – March 9, 2009 -21.94% -16.08% $2194.20 $0.00 $0.00 $0.00
Policy-led rebound / euro-sovereign-crisis overlay March 10, 2009 – July 25, 2012 -5.17% -1.56% $516.72 $0.00 $0.00 $0.00
Secular stagnation / QE / low inflation / duration bull July 26, 2012 – February 19, 2020 +384.16% +23.17% +$38415.69 $0.00 $0.00 $0.00
Pandemic shock / liquidity crash February 20, 2020 – March 23, 2020 -32.13% -98.80% $3212.60 $0.00 $0.00 $0.00
Policy bazooka / monetary euphoria March 24, 2020 – November 6, 2020 +8.48% +13.99% +$847.65 $0.00 $0.00 $0.00
Reopening reflation / fiscal boom / supply bottlenecks November 9, 2020 – November 29, 2021 -45.21% -43.49% $4520.96 $0.00 $0.00 $0.00
Inflation shock / duration crash / aggressive tightening November 30, 2021 – November 9, 2022 +62.49% +67.44% +$6249.06 $0.00 $0.00 $0.00
Disinflation rebound / AI-led narrow bull / higher-for-longer November 10, 2022 – September 17, 2024 -8.71% -4.80% $870.90 $0.00 $0.00 $0.00
Disinflationary easing / resilient growth / AI capex under oil-shock test partial September 18, 2024 – June 3, 2026 +74.27% +38.49% +$7426.82 $0.00 $0.00 $0.00

Dividend History

Date Per Share Yield %
Total 0 payments
No dividends recorded.

All calculations use split-adjusted closing prices. Dividends are reinvested on the ex-dividend date at that day's closing price.

For each rolling window, returns are calculated at every possible starting point:

return = (value[i] ÷ value[i − windowSize] − 1) × 100

Windows
1-month = 21 trading days, 1-year = 252 trading days, 3-year = 756 trading days.
Statistics
Average: arithmetic mean. Median: middle value when sorted. Best / Worst: max and min. % Positive: share of windows with return > 0.

The series is segmented by calendar year:

return = (endValue ÷ startValue − 1) × 100

startValue is the last value of the prior year (or the first value for the initial year). Partial first/last years are flagged. Dividends, taxes, and transaction costs are scaled proportionally to the initial investment.

SBCF

CAGR 4.03% Total 432.06% Final $53,206
1984-02-02 — 2026-06-03
BKD

CAGR -3.00% Total -46.50% Final $5,350
2005-11-22 — 2026-06-03
INGN

CAGR -7.28% Total -60.53% Final $3,947
2014-02-14 — 2026-06-03